Lab Introduction

The study of laboratory focuses on investigating non-alcoholic fatty liver disease in laying hens. The fatty liver model of hens is used to screen for potential compounds of alleviating disease and explore the molecular mechanisms of their effects. The experimental findings have been published at international conferences, with the research theme centered on the efficacy of a native herbal plant--Phyllanthus urinaria, on improving NAFLD in laying hens and elucidating its underlying mechanisms. Notably, fatty liver in hens may lead to a decline in egg production rates, resulting in economic losses. Additionally, due to the similarity in the mechanisms of de novo lipid synthesis between chickens and humans, laying hens serve as a valuable model for simulating NAFLD in humans. Through animal experiments, it has been demonstrated that Phyllanthus urinaria can reduce plasma triglycerides and total cholesterol, thereby ameliorating hyperlipidemia, and simultaneously improving liver pathology scores. Furthermore, Phyllanthus urinaria can enhance antioxidant enzymes in the liver, reducing oxidative stress. The outcomes of our laboratory's research are considerable potential, and the extension of these studies can serve as a crucial foundation for the development of relevant pharmaceuticals or products.