Nucleotide Research Laboratory
Principal Investigator : Prof. Zee-Fen CHANG
Team Size : 14
Study Field : Nucleotide Regulation Coupled with DNA Damage Responses to Dictate Genome Integrity, Mitochondrial Quality Control, and Mito-nuclear Communication in Cormal and Cancer Cells.
Forms of Int'l Cooperation : Personnel Exchange, Student Exchange
Lab Introduction
The mammalian genomes are comprised of nuclear DNA and hundreds to thousands of copies of mitochondrial DNA. In one’s lifetime, DNA lesions in the genome are constantly generated due to endogenous and exogenous exposure to genotoxic chemicals from all sources. Removal of these DNA damages with correct and sufficient nucleotide incorporation is essential for maintaining nuclear and mitochondrial genome stability, which has a consequent impact on health and disease. We are interested in how nucleotide regulation is coupled with DNA damage responses to dictate genome integrity, mitochondrial quality control, and mito-nuclear communication in normal and cancer cells. Our long-termed goal is to develop novel therapeutic and prevention strategies against diseases by manipulating DNA metabolism separately in nuclei and mitochondria through targeting nucleotide enzymes and their regulatory pathways.
International Cooperation Experience
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Thomas Jefferson University | NME3 in Mitochondrial Calcium Signal | United States of AmericaJoint Research Project
2024/03/18 ~ 2024/03/18
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Tony Hunter, Salk Institute | NME3 Histidine Phosphorylation | United States of AmericaJoint Research Project
2024/03/18 ~ 2024/03/18
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Technion Faculty of Medicine | NME3 in neurodegenerative disorder | Israel
2024/03/18 ~ 2024/03/18
Contact
Yung-Chin YEH
Position : Administrative Assistant
Email : yychin@ntu.edu.tw
Phone : +8862-2312-3456 #288591
Principal Investigator
Position : Chair Professor, Medicine Institute of Molecular Medicine
Email : zfchang@ntu.edu.tw
Education / Background :