Lab Introduction

Led by Professor Pai-Shan Chen, our laboratory stands at the intersection of Analytical Chemistry, Clinical Toxicology, and Multi-omics, dedicated to developing innovative mass spectrometry (MS) platforms to address complex challenges in clinical and forensic sciences.

Our core expertise lies in Advanced Mass Spectrometry Development and Application. We specialize in designing high-sensitivity detection systems, including 3D-printed paper-based microfluidic devices, paper spray ionization, and aptamer-functionalized chips. These technologies, coupled with advanced signal enhancement strategies, enable the ultra-trace detection of miRNA and emerging psychoactive substances in complex matrices.

In the realm of Clinical Chemistry and Precision Diagnostics, we bridge the gap between fundamental chemistry and medical application. By conducting in-depth mechanistic studies on oximation and silylation derivatization, we exert precise control over in-source fragmentation. These chemical innovations significantly enhance the diagnostic accuracy for metabolic disorders such as Organic Acidemias and Pheochromocytoma.

Furthermore, we are pioneers in Wastewater-Based Epidemiology (WBE) and large-scale drug screening. Our team establishes robust high-throughput methods to monitor multiple drugs of abuse and their metabolic pathways, facilitating the discovery of critical biomarkers. By analyzing consumption patterns within communities, we provide evidence-based data essential for public health policy and environmental risk assessment.

Our commitment to Metabolomics and Exposomics extends to the comprehensive profiling of small molecules, lipids, and DNA adducts. By integrating computational lipidomics and data visualization, we investigate the molecular mechanisms of disease and addiction. Through interdisciplinary collaboration and the use of nanomaterial-enhanced sensing (SALDI-MS), our laboratory continues to push the boundaries of analytical science to improve global health and forensic integrity.