Lab Introduction

The Ultrafast Optics Laboratory (UFO), or Ultrafast nano-Optics and biophotonics Laboratory, led by Professor Chi-Kuang Sun at National Taiwan University, is internationally recognized for pioneering research in ultrafast science, terahertz (THz) acoustics, THz fibers, and advanced biophotonics. Our multidisciplinary team explores the fundamental interactions between light, sound, and matter on femtosecond timescales, enabling breakthroughs that bridge physics, materials science, and biomedical engineering.

A central focus of the laboratory is Nano-ultrasonics and THz acoustics. Professor Sun’s group has made landmark contributions to the generation and detection of coherent acoustic phonons up to multi-THz frequencies, revealing new phenomena in interfacial water, semiconductor heterostructures, and van der Waals materials. These advances have established new principles for probing mechanical, thermal, and structural properties at nanometer and atomic scales.

In parallel, the lab develops cutting-edge biophotonic imaging technologies, including label-free third-harmonic-generation (THG) microscopy, color-resolved THG chemical imaging, free-intraepidermal nerve ending scope (FINEscope), and deep-brain two-photon miniScope. These methods allow noninvasive interrogation of biological structures, nerve function, and vascular function with unprecedented resolution and minimal photodamage. Recent achievements include quantifying glycated hemoglobin in single red blood cells, real-time monitoring of small nerve fibers in vivo, and slide-free rapid fresh pathology imaging for immediate clinical diagnostics.

The laboratory maintains strong collaborations with leading groups in the United States, Europe, and Asia, and actively translates optical innovations into biomedical and industrial applications. With state-of-the-art femtosecond laser systems, ultrafast spectroscopy tools, and advanced imaging platforms, the group provides a dynamic environment for students and researchers dedicated to pushing the frontiers of ultrafast science and optical biotechnology.

Professor Sun’s laboratory continues to pursue transformative research that expands our understanding of ultrafast phenomena while advancing next-generation technologies for materials characterization, medical diagnostics, and precision health.